562823-84-1

Name	3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE
CAS	562823-84-1
Molecular Formula	C15H12BIO3
MDL Number	MFCD06798340
Molecular Weight	377.97
MOL File	562823-84-1.mol

Synonyms

MDM2 Inhibitor TRANS-4-IODO,4'-BORANYL-CHALCONE MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem 3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE 3-(4-IODO-PHENYL)-1-(4''- BORANYL-PHENYL)-PROP-2-ENONE (FOR R&D ONLY) Boronic acid, B-[4-[(2E)-3-(4-iodophenyl)-1-oxo-2-propen-1-yl]phenyl]-

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Chemical Properties

storage temp.	+2C to +8C
solubility	DMSO: >30 mg/mL, soluble
form	solid

Safety Data

WGK Germany

Hazard Information

Definition

ChEBI: [4-[3-(4-iodophenyl)prop-2-enoyl]phenyl]boronic acid is a member of chalcones.

General Description

A cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC₅₀ = 10 μM for MDA-MB-435, 8.8 μM for MDA-MB-231, and 7 μM for Wt-MCF7) compared to normal breast cell lines (IC₅₀ = 75 μM for MCF-10A and 63 μM for MCF-12A).

Biochem/physiol Actions

Cell permeable: yes

Supplier

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai Haohong Scientific Co., Ltd.

Telephone400-400-8210725

Websitehttps://www.leyan.com/

Yantai Lianhua Technology Co., Ltd

Telephone 15552437730

Website

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Telephone +86-18521732826

Websitehttp://www.aladdin-e.com/

Shaoguan Qicheng Biotechnology Co., Ltd

Telephone 18122215013

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1488808/0.htm

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