56-49-5

Yellow crystals or solid.

3-METHYLCHOLANTHRENE(56-49-5) can react with oxidizing materials. Ozone and chlorinating agents oxidize this chemical.

Insoluble in water.

Powerful carcinogen.

The coke-oven plant is the principal source of coal tar. The hot gases and vapors produced during the conversion of coal to coke are collected by means of a scrubber, which condenses the effluent into ammonia, water, crude tar, and other by-products. Crude tar is separated from the remainder of the condensate for refining and may undergo further processing. Employees may be exposed to pitch and creosote in metal and foundry operations; when installing electrical equipment; in construction, railway, utility; and briquette manufacturing.

Flash point data for this chemical are not available; however, 3-METHYLCHOLANTHRENE is probably combustible.

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

UN1136 Coal tar distillates, flammable, Hazard Class: 3; Labels: 3-Flammable liquid

Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Phenols, such as creosote react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Flammable hydrogen gas is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid

3-Methylcholanthrene (3-MC) is a member of the polycyclic aromatic hydrocarbon (PAH) family and is used as an experimental cancer research chemical. As other PAHs, 3-MC might be found in trace quantities in coal tar and heavy-end petroleum hydrocarbons.

3-Methylcholanthrene is a solid that crystallizes from benzene and ether as pale yellow prisms. 3-methylcholanthrene is insoluble in water and soluble in alcohol. It is combustible, and can react with oxidizing materials.

The term “coal tar products,” as used by NIOSH, includes coal tar and two of the fractionation products of coal tar, creosote and coal tar pitch, derived from the carbonization of bituminous coal. Coal tar, coal tar pitch, and creosote (coal tar creosote 8001-58-9) derived from bituminous coal often contain identifiable components which by themselves are carcinogenic, such as benzo(a) pyrene, benzanthracene, chrysene, and phenanthrene. Other chemicals from coal tar products, such as anthracene, carbazole, fluoranthene, and pyrene may also cause cancer,but these causal relationships have not been adequately documented. Also, the research chemical methylcholanthrene (CAS: 56-49-5), a powerful carcinogen, fits this category. Coal tar pitch is a black viscous liquid. Aromatic solvent odor. Boiling point =>260°C; specific gravity (H2O:1) = 1.07-108; freezing/melting point = 250-°180C;flash point = 207°C (coal tar pitch); 74C (creosote oil);autoignition temperature =>510°C. Insoluble in water.Coal tar creosote (8001-58-9, crosote) is an black oily,tar-like substance. Pungent odor

Yellow Crystalline Solid

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

3-MC is used experimentally as a positive control in cancer research and in biochemical research to induce specific forms of cytochrome P450. Other than this, there is no particular use for this chemical except as a possible chemical intermediate.

A carcinogen

ChEBI: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.

The Journal of Organic Chemistry, 47, p. 2120, 1982 DOI: 10.1021/jo00132a026

3-Methylcholanthrene is a carcinogen used to induce transformation of cultured cells. It is also used to induce fibrosarcomas and skin carcinomas in laboratory animals. 3-methylcholanthrene is a potent aryl hydrocarbon receptor agonist.

3-Methylcholanthrene is a rapid, all-around neoplastic agent and a potent liver tumorigen.

3-MC, when released to soil, adsorbs strongly to the soil and does not leach. It does not biodegrade or hydrolyze significantly but may evaporate from dry soil. If released to water, it is expected to adsorb strongly to sediment and to bioconcentrate in aquatic organisms. If released into the atmosphere, it may be subject to direct photolysis because it absorbs strongly in the ultraviolet (UV) spectrum of light. It may also react with peroxyl radicals already present in the atmosphere. Its estimated half-life in the atmosphere is 2.8 h. Considering an octanol/ water log concentration ratio of 6.42, a bioconcentration factor of 45 000 has been estimated.

Metabolic activation of PAHs consists of oxidation of the rings of unsubstituted PAHs. These oxidations are carried out by mixed function oxidases of the liver, which contain cytochromes P450 and P448 and require reduced nicotine adenine dinucleotide and oxygen. In this oxidation, an epoxide intermediate is formed that has been shown to have the requisite chemical reactivity to bind covalently with DNA and histones and to serve as the ultimate carcinogenic form of PAH. Administration of 3- MC to rats increased hepatic nuclear proteins and caused a turnover of protein of the endoplasmic reticulum. Studies of 14C amino acid incorporation showed that 3-MC causes increased protein synthesis and reduced degradation of protein.