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55406-53-6

Name Iodopropynyl butylcarbamate
CAS 55406-53-6
EINECS(EC#) 259-627-5
Molecular Formula C8H12INO2
MDL Number MFCD00072438
Molecular Weight 281.09
MOL File 55406-53-6.mol

Chemical Properties

Description
Iodopropynyl butylcarbamate is a preservative that has been used as an industrial fungicide since the 1970s and more recently has been combined with formaldehydereleasing agents for use in cosmetics. The North American Contact Dermatitis Group patch tested with 0.1%iodopropynyl butylcarbamate in petrolatum and found 0.2% of their patch test clinic patients had positive reactions to this chemical. Most cosmetic applications appear to require less than 0.012% of this preservative.
Appearance Liquid
Melting point  64-68 °C(lit.)
Boiling point  321.8±25.0 °C(Predicted)
density  1.606±0.06 g/cm3(Predicted)
vapor pressure  0.005Pa at 25℃
storage temp.  Refrigerator
solubility  soluble in Methanol
form  neat
pka 12.03±0.46(Predicted)
Stability: Stable. Incompatible with strong oxidizing agents.
Water Solubility  168mg/L at 20℃
Usage Glycacil(R) 2000 is used as a preservative in personal care formulations.
Merck  14,5069
Contact allergens
Iodopropynyl butylcarbamate has produced slight irritation in rabbits. However, it was not found to be either a skin sensitizer or a photo sensitizer in guinea pigs. Cosmetic formulations containing up to 0.125% of iodopropynyl butylcarbamate produce no significant irritation or sensitization reactions in human repeated insult patch tests. Iodopropynyl butylcarbamate did not cause crosssensitization reactions in patients who had demonstrated sensitivity to related dithiocarbamate compounds. In the European Union, it is approved as a preservative up to 0.05% and is not to be used in oral hygiene or lip care products. If the concentration exceeds 0.02% in leave-on products, a warning label must indicate that the product contains iodine.
InChIKey WYVVKGNFXHOCQV-UHFFFAOYSA-N
Uses
iodopropynyl butylcarbamate is a preservative with broad fungicidal activity used in skin care products. It is recommended for use in difficult formulation systems.
CAS DataBase Reference 55406-53-6(CAS DataBase Reference)
EPA Substance Registry System 55406-53-6(EPA Substance)

Safety Data

Hazard Codes  N
Risk Statements 
Safety Statements 
RIDADR  3077
WGK Germany  3
RTECS  EZ0950000
HazardClass  9
PackingGroup  III
HS Code  29241990
Hazardous Substances Data 55406-53-6(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 1580 mg/kg; dermally in rabbit: >2000 mg/kg; LC50 (96 hr) in bluegill sunfish, rainbow trout, bobwhite quail: 1.12, 0.31, >7683 ppm; LC50 (8 day) in mallard duck: >7182 ppm (Hansen)

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