General Description
Green to dark green powder.
Reactivity Profile
HEXAMETHYL-P-ROSANILINE CHLORIDE(548-62-9) is light sensitive. . May react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release gaseous hydrogen.
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data for this compound are not available, however, HEXAMETHYL-P-ROSANILINE CHLORIDE is probably combustible.
Description
Anti-infective (topical). Has been used as anthelmintic (Nematodes), as indicator for copper salts.
Description
Crystal Violet is light sensitive. May react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release gaseous hydrogen.
Chemical Properties
dark green powder or crystals
Chemical Properties
This is a perennial, herbaceous plant native to mountainous areas of Europe; it may reach 0.5 to 1.0 m (2 to 3 ft) in height It has large, cylindrical roots (internally yellow); erect chalice; and fowers with a yellow corolla and peduncles It blooms from July to August The part used is the root of two-year-old plants The color of the rhizomes ranges from dark brown to light tan The color of roots appears to be related to its bitter principle content The dried product and its derivatives of gentian exhibit a very bitter favor.
Occurrence
Gentian is a fl owering perennial found in Europe and Asia.
Uses
As dye for wood, silk, paper; in inks; as biological stain.
Definition
ChEBI: Crystal violet is an organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain. It has a role as a histological dye, an antiseptic drug, an antibacterial agent, an antifungal agent and an anthelminthic drug. It contains a crystal violet cation.
Brand name
Genapax (Key); Gvs (Savage).
Essential oil composition
A number of bitter compounds present in gentian are primarily amarogentin (strongly bitter), gentiopricin
(approximately 1.5% in fresh root), swertiamarin and gentiopricroside. The leaves and flowers contain mainly xanthones.
Secoiridoids and flavonoids were also detected. In the phase of flowering, leaves are rich with compounds possessing C-glycoside
structures while O-glycoside structures accumulate mainly before flowering.
Flammability and Explosibility
Notclassified
Biochem/physiol Actions
Crystal violet can be used for DNA visualization in agarose gels. The dye is used only in the presence of high concentrations of DNA. Crystal violet is also used for the staining of bacteria in gram staining technique. It is also used for the staining of plant chromosomes. Crystal Violet also helps in colorimetric measurement of cell viability.
Clinical Use
Gentian violet is variously known as hexamethyl-p-rosanilinechloride, crystal violet, methyl violet, and methylrosanilinechloride. It occurs as a green powder or greenflakes with a metallic sheen. The compound is soluble inwater (1:35) and alcohol (1:10) but insoluble in nonpolar organicsolvents. Gentian violet is available in vaginal suppositoriesfor the treatment of yeast infections. It is also used asa 1% to 3% solution for the treatment of ringworm and yeastinfections. Gentian violet has also been used orally as an anthelminticfor strongyloidiasis (threadworm) and oxyuriasis.
storage
4°C, protect from light
Properties and Applications
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TEST ITEMS
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SPECIFICATION
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APPEARANCE
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DARK GREEN POWDER OR GRANULE
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SHADE
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BLUISH
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HEAT RESISTANCE
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200 °C min
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DENSITY
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1.07 g/cm
3
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WATER FASTNESS
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4-5
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LIGHT FASTNESS
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1-2
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BLEACHABILITY (OXIDATIVE)
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4
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BLEACHABILITY (REDUCTIVE)
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3
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WATER SOLUBILITY AT
25 °C
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16 g/L min
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WATER INSOLUBLE
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1.0% max
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MOISTURE
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3.0% max
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TINTING STRENGTH
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100-105 %
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WEIGHT METAL TOTAL
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50ppm max
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Purification Methods
Crystallise the dye from water (20mL/g), the crystals being separated from the chilled solution by centrifugation, then wash them with chilled EtOH (solubility is 1g in 10 mL of hot EtOH) and diethyl ether and dry under vacuum. It is soluble in CHCl3 but insoluble in Et2O. The carbinol is precipitated from an aqueous solution of the dye-hydrochloride, using excess NaOH, then dissolve in HCl and recrystallise it from water as the chloride [UV and kinetics: Turgeon & La Mer J Am Chem Soc 74 5988 1952]. The carbinol base has m 195o (needles from EtOH). The diphthalate (blue and turns red in H2O) crystallises from H2O, m 153-154o(dec at 185-187o)[Chamberlain & Dull J Am Chem Soc 50 3089 1928]. [Beilstein 13 H 233, 13 IV 2284.]
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