545-55-1

Name	TEPA
CAS	545-55-1
EINECS(EC#)	208-892-5
Molecular Formula	C6H12N3OP
MDL Number	MFCD00081201
Molecular Weight	173.15
MOL File	545-55-1.mol

Chemical Properties

Appearance	Colorless crystals. Soluble in water, alcohol, and ether. Combustible.
Melting point	41℃
Boiling point	299℃
density	1.47
Fp	135℃
storage temp.	-20°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	solid
pka	2.74±0.20(Predicted)
Stability:	Stable.
biological source	rabbit
IARC	3 (Vol. 9, Sup 7) 1987
EPA Substance Registry System	Aziridine, 1,1',1''-phosphinylidynetris- (545-55-1)

Safety Data

RIDADR	2811
HazardClass	6.1(b)
PackingGroup	III
Safety Profile	Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. A corrosive irritant to the skin, eyes, and mucous membranes. When heated to decomposition it emits very toxic fumes of POx and NOx. Used as an acaricide and in the permanentpress treatment of cotton. less more
Hazardous Substances Data	545-55-1(Hazardous Substances Data)
Toxicity	LD50 orally in male rats: 37 mg/kg (Gaines) less more

Hazard Information

Chemical Properties

colourless granules

Uses

Used as insect chemosterilant; in dyeing. Antineoplastic.

Uses

Insect chemosterilant; in dyeing, creaseproofing and flameproofing textiles; stabilizer for polymers; in photographic emulsion hardening.

General Description

An aqueous solution of a colorless crystalline solid. Toxic by skin absorption, ingestion or inhalation. Produces toxic oxides of nitrogen during combustion. Used as a pesticide.

Reactivity Profile

TRIS-(1-AZIRIDINYL) PHOSPHINE OXIDE may react with aqueous solutions of acids or strong bases. Undergoes slow decomposition in water, not considered hazardous. Polymerizes violently at about 255°F. Acid fumes also cause polymerization at ordinary temperatures [USCG, 1999]. May produce highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Health Hazard

Inhalation (unlikely unless a heavy mist is formed) causes symptoms similar to those observed after ingestion. Contact with liquid or powder causes irritation of eyes and (on prolonged contact) irritation and burns of skin. Burns are slow to develop and slow to heal. May sensitize on repeated contact. Ingestion causes depression, anorexia, and diarrhea, appearing 2-3 days before death, followed by terminal dyspnea, incoordination, epistaxis, salivation, prostration and cyanosis.

Fire Hazard

Special Hazards of Combustion Products: Phosphoric acid mist may form in fire. Toxic oxides of nitrogen may form.

Definition

ChEBI: Tris(1-aziridinyl)phosphine oxide is a phosphoramide.

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