5413-85-4

4316-93-2

5413-85-4

GENERAL METHODS: 10% Pd/C catalyst (0.05 g) was added to a solution of 4,6-dichloro-5-nitropyrimidine (4.48 mmol) in ethyl acetate (EA, 20 mL) in a Parr hydrogenation reactor. Subsequently, the air in the reactor was replaced with nitrogen three times and the hydrogenation reaction was carried out at room temperature and at atmospheric pressure. Upon completion of the reaction, the reaction solution was filtered through a diatomaceous earth filter to remove the Pd/C catalyst, and the filtrate was concentrated to give the target product 4,6-dichloro-5-aminopyrimidine [46].