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541-41-3

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Identification

Name
Ethyl chloroformate
CAS
541-41-3
Synonyms
AKOS BBS-00004329
Carbonchloridic acid ethyl ester
CHLOROFORMIC ACID ETHYL ESTER
ECF
ETHOXYCARBONYL CHLORIDE
ETHYL CHLOROCARBONATE
ETHYL CHLOROFORMATE
Carbonochloridicacid,ethylester
carbonochloridicacidethylester
Cathyl chloride
cathylchloride
chlorameisensaeureaethylester
Chlorocarbonate D'ethyle
chlorocarbonated’ethyle
chlorocarbonated’ethyle(french)
Chlorocarbonic acid, ethyl ester
chlorocarbonicacidethylester
chloro-formicaciethylester
Choroformicester
Clhorameisensaeureaethylester
EINECS(EC#)
208-778-5
Molecular Formula
C3H5ClO2
MDL Number
MFCD00000644
Molecular Weight
108.52
MOL File
541-41-3.mol

Chemical Properties

Appearance
A colorless to light yellow liquid. Sharp, pungent odor, similar to HCl.
Appearance
Colorless to yellow liquid
mp 
-81 °C
Melting point 
-81 °C (lit.)
Boiling point 
93 °C (lit.)
bp 
94 °C
density 
1.139 g/mL at 20 °C

vapor density 
3.74 (vs air)

vapor pressure 
3.42 psi ( 20 °C)

refractive index 
n20/D 1.395(lit.)

Fp 
57 °F

storage temp. 
2-8°C

form 
Liquid
color 
White to off-white
Odor
Irritating; sharp, like hydrochloric acid.
Water Solubility 
decomposes
Sensitive 
Moisture Sensitive
Merck 
14,3784
BRN 
385653
CAS DataBase Reference
541-41-3(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, ethyl ester(541-41-3)
EPA Substance Registry System
541-41-3(EPA Substance)

Safety Data

Hazard Codes 
F,T+
Risk Statements 
R11:Highly Flammable.
R22:Harmful if swallowed.
R26:Very Toxic by inhalation.
R34:Causes burns.
Safety Statements 
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S33:Take precautionary measures against static discharges .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 1182 6.1/PG 1

WGK Germany 
1

RTECS 
LQ6125000


10-19-21
Autoignition Temperature
842 °F
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
I
HS Code 
29151300
Safety Profile
Poison by ingestion, inhalation, and intraperitoneal routes. Moderately toxic by skin contact. Corrosive. An eye, skin, and mucous membrane irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. Reacts with water or steam to produce toxic and corrosive fumes. To fight fire, use CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of Cl-.
Hazardous Substances Data
541-41-3(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
A colorless liquid with a pungent odor. Flash point 66°F. Very toxic by inhalation. Corrosive to metals and tissue. Vapors are heavier than air. Prolonged exposure to low concentrations or short exposure to high concentrations may have adverse health effects from inhalation.
Reactivity Profile
ETHYL CHLOROFORMATE(541-41-3) decomposes slowly in water to form ethanol, HCl, and CO2 Attacks many metals especially in humid atmosphere [Handling Chemicals Safely 1980. p. 476]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Air & Water Reactions
Highly flammable. Emits fumes containing HCl on contact with moist air. Decomposes exothermically but slowly in water.
Hazard
Flammable, dangerous fire risk. Strong irritant to eyes and skin.
Health Hazard
Inhalation causes mucous membrane irritation, coughing, and sneezing. Vapor causes severe lachrymation; liquid causes acid-type burns of eyes and skin, like those of hydrochloric acid. Ingestion causes severe burns of mouth and stomach.
Potential Exposure
Heavily used in industry for various processes; in ore processing, photography, making other chemicals including amines, carbamates, isocyanates; polymers, diethyl carbonate; nitriles, etc.
First aid
Inhalation: remove to fresh air; use artificial respiration if breathing has stopped; call a doctor; keep victim quiet and administer oxygen if needed. Eyes: flush with water for at least 15 min.; see a doctor. Skin: wash liberally with water for at least 15 min., then apply dilute solution of sodium bicarbonate or commercially prepared neutralizer. Ingestion: do NOT induce vomiting; give large amount of water; get medical attention
Fire Hazard
Special Hazards of Combustion Products: Toxic chlorine and phosgene gases may be formed in fires.
Shipping
UN1182 Ethyl chloroformate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, 8-Corrosive material Inhalation Hazard Zone B
Incompatibilities
Highly flammable; Vapors may form explosive mixture with air. Emits fumes containing HCl on contact with moist air. Decomposes exothermically but slowly in water. Ethyl chloroformate decomposes slowly in water forming ethanol, hydrogen chloride and carbon dioxide. May react vigorously, possibly explosively, if mixed with di-isopropyl ether or other ethers in the presence of trace amounts of metal salts. Reacts with acids, alkalies, amines, alcohols, oxidizers and water. Corrosive to metals especially in the presence of moisture.
Chemical Properties
Ethyl chloroformate is a colorless to light yellow liquid that is corrosive and flammable. It is prepared from phosgene and ethanol. It has a sharp pungent odor, like hydrochloric acid, and it decomposes in water. It is miscible with alcohol, benzene, chloroform, and ether.
Waste Disposal
Use a licensed professional waste disposal service to dispose of this material. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices
Uses
Ethyl chloroformate (chloroformic acid ethyl ester) is used as a solvent in the photographic industry, and as a chemical intermediate in the production of various carbamates, and used in synthesis of dyes, drugs, veterinary medicines, herbicides, and insecticides. It is also used in the production of flotation agents for ores, as a stabilizer for PVC, and in the production of modified penicillins and heterocyclic compounds (Gerhartz, 1985).
Cathyl Chloride is used in the preparation of new inhibitors for β-homocysteine S-methyltransferase. Also used in the synthesis of a hexosaminidase inhibitor.
Preparation
Ethyl chloroformate was used in the synthesis of nitrile oxides. It can be obtained synthetically by the reaction between phosgene and anhydrous ethanol.
Ethyl chloroformate is chlorinated in the rectifying zone of a distillation reactor to produce 1-chloroethyl chloroformate and 2-chloroethyl chloroformate.
Chemical Reactivity
Reactivity with Water: Slow reaction with water, evolving hydrogen chloride (hydrochloric acid); Reactivity with Common Materials: Slow evolution of hydrogen chloride from surface moisture reaction can cause slow corrosion; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water, rinse with sodium bicarbonate or lime solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Purification Methods
Wash the ester several times with water, redistil it using an efficient fractionating column at atmospheric pressure and a CaCl2 guard tube to keep free from moisture [Hamilton & Sly J Am Chem Soc 47 435 1925, Saunders et al. J Am Chem Soc 73 3796 1951]. [Beilstein 3 IV 23.] LACHRYMATORY AND TOXIC.

Material Safety Data Sheet(MSDS)

Spectrum Detail

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