Supplier Related Products Identification Chemical Properties Hazard Information
ChemicalBook >  CAS DataBase List  > 540769-28-6

540769-28-6

Supplier Related Products Identification Chemical Properties Hazard Information

Product Image

Identification

Name
Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-
CAS
540769-28-6
Synonyms
Palosuran
ACT 058362
PALOSURAN,, >98%
ACT058362;ACT-058362
ACT 058362; PALOSURAN,
ACT 058362; PALOSURAN,, >98%
1-[2-(4-Benzyl-4-hydroxypiperidin-1-yl)ethyl]-3-(2-methylquinolin-4-yl)urea
N-[2-[4-Hydroxy-4-(phenylmethyl)-1-piperidinyl]ethyl]-N'-(2-methyl-4-quinolinyl)urea
Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-
Molecular Formula
C25H30N4O2
MOL File
540769-28-6.mol
Molecular Weight
418.53

Chemical Properties

Boiling point 
612.9±55.0 °C(Predicted)
density 
1.235±0.06 g/cm3(Predicted)
pka
12.95±0.43(Predicted)

Hazard Information

Description
Palosuran is an antagonist of the urotensin II receptor (UTR; IC50s = 3.6 and 1,475 nM for CHO cell membranes expressing human and rat recombinant receptors, respectively). It inhibits contraction of isolated rat aortic rings induced by urotensin II (Item Nos. 24711 | 24753) in a concentration-dependent manner. Palosuran (300 mg/kg twice per day) reduces plasma endothelin-1 (Item No. 24127), urotensin II, and TGF-β1 levels, as well as the main pulmonary arterial pressure and right ventricular hypertrophy index in a rat model of pulmonary arterial hypertension (PAH) induced by monocrotaline (Item No. 16666). Palosuran (300 mg/kg per day) reduces serum glucose, cholesterol, and triglyceride levels and increases survival in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104). It also decreases albuminuria and global kidney lesion scores in STZ-induced diabetic rats.
SupplierMore