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Hazard Information

Material Safety Data Sheet(MSDS)

Questions And Answer

• Anti-motion sickness

  Dimenhydrinate is a complex salt of diphenhydramine and 8-chloro-theophylline. Antihistamine effect is weaker than diphenhydramine , and its anti-motion sickness and antiemetic effects are stronger. Mainly it is used to prevent and control nausea, vomiting, dizziness and Meniere's syndrome caused by motion sickness, .It is effective to treat a variety of dizziness, vomiting caused by radiation therapy, pregnancy, surgery, inner ear infections, and the use of drugs (such as streptomycin) . ;

• Traits

  Dimenhydrinate is transparent white crystalline powder, odorless, slightly soluble in water, soluble in ethanol. ;

• Effect

  As a complex salt of diphenhydramine and 8-chloro-theophylline,its role is the same as diphenhydramine hydrochloride, but its anti-histamine effect is weaker than the latter. It can inhibit medulla vomiting chemosensory area and it has a general central pivot inhibition effect and anticholinergic effects, which makes it have sedative and antiemetic effects.
  It is quickly and completely absorbed after oral administration, it is effective after 15 to 60 minutes , the role is sustainable after 3-6 hours, the elimination phase half-life (t1/2β) is 4~6 hours, plasma protein binding rate is high. Mainly it is metabolized in the liver, it is excreted in urine in the form of metabolites . Patients with hepatic insufficiency using this service,because it can accumulate in the body , the dose should be reduced.
  The above information is edited by the chemicalbook of Tian Ye. ;

• Medicine interactions

  1.It can not be taken with other CNS depressants and it cannot be taken after drinking.
  2. It can be used to make ethanol, central nervous system depressants, tricyclic antidepressants more effective. It can momentarily affect barbiturates and sulfacetamide sodium absorption; if it is used with sodium aminosalicylate , plasma concentration of the latter is decreased.
  3. Administration with food or milk can reduce the irritation of the stomach of the drug . ;

• Precautions

  1. The composition of the production and other ethanolamine allergies, newborns and premature infants are disabled.
  2. It pregnant women in early pregnancy within four months use the drug, the incidence of congenital cardiovascular abnormalities and inguinal hernia of the fetus may be increased, the relationship with drug use has not been confirmed. Early pregnancy should not take this product.
  3. The anti-emetic effect of the product can adds difficulty in diagnosing appendicitis and drug-induced reactions.
  4. Lethargy , inability to concentrate etc.,can occur after treatment, ,patients should not drive cars, boats, etc., and it is not suitable to engage in the highly difficult and dangerous machine operation. ;

• Adverse reactions

  Low toxicity, high doses can cause drowsiness, and even cause a rash. Long-term use may cause blood diseases. ;

• Uses

  It is suitable for motion-sickness, pregnancy, radiation therapy , surgery etc. induced nausea , vomiting and dizziness. ;

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