520-65-0

A pyrrolizidine alkaloid isolated from Senecio rosmarinifolium Linn., the base crystallizes as glistening laminae from either EtOH or Me2CO. It has [α]²⁴_D - 91.5° (MeOH) or - 94° (EtOH) and yields a crystalline nitrate, m.p. 218°C (dec.); [α]²⁰_D - 91.5° (H20) and a methiodide, m.p. 251°C. On alkaline hydrolysis it furnishes rosmarinecine, CsH1S0 3N, m.p. 171-2°C; [α]²⁵_D - 118.5° (MeOH) and senecic acid, ClOH160 S, m.p. 151°C; [α]²⁵_D + 11.8° (EtOH).

ChEBI: Rosmarinine is a macrolide.