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MLS000536924 is a potent and selective competitive inhibitor of human epithelial 15-lipoxygenase-2 (15-LOX-2).

MLS000536924 is a potent and selective inhibitor of human epithelial 15-lipoxygenase-2 with competitive activity. MLS000536924 exhibits more than 50-fold selectivity in inhibiting h15-LOX-2 and can be effectively applied to study its role in atherosclerosis, cystic fibrosis, and ferroptosis. The binding mode of MLS000536924 shows stronger restriction of protein movement than other inhibitors, further verifying its higher biological activity[1].

[1] Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2