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50-02-2

Name Dexamethasone
CAS 50-02-2
EINECS(EC#) 200-003-9
Molecular Formula C22H29FO5
MDL Number MFCD00064136
Molecular Weight 392.46
MOL File 50-02-2.mol

Chemical Properties

Appearance White or almost white, crystalline powder.
Melting point  262-264 °C (lit.)
alpha  75 º (c=1, dioxane)
Boiling point  568.2±50.0 °C(Predicted)
density  1.1283 (estimate)
refractive index  76 ° (C=1, Dioxane)
Fp  9℃
storage temp.  2-8°C
solubility  ethanol: 1 mg/mL
form  powder
pka 12.13±0.70(Predicted)
color  off-white
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
Water Solubility  10 mg/100 mL (25 ºC)
Sensitive  Light Sensitive
Usage A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase
Merck  14,2943
BRN  2066651
BCS Class 1 (CLogP), 3 (LogP)
InChIKey UREBDLICKHMUKA-CXSFZGCWSA-N
CAS DataBase Reference 50-02-2(CAS DataBase Reference)
NIST Chemistry Reference Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2)
EPA Substance Registry System 50-02-2(EPA Substance)

Safety Data

Hazard Codes  Xi,Xn
Risk Statements 
R43:May cause sensitization by skin contact.
R40:Limited evidence of a carcinogenic effect.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements 
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S22:Do not breathe dust .
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  TU3980000
TSCA  Yes
HS Code  29372200
Safety Profile
Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of F-.
Hazardous Substances Data 50-02-2(Hazardous Substances Data)
Toxicity
LD50 oral in rat: > 3gm/kg

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