Supplier Related Products Identification Chemical Properties Questions And Answer Hazard Information Safety Data
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489-32-7

Supplier Related Products Identification Chemical Properties Questions And Answer Hazard Information Safety Data

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Identification

Name
Icariin
CAS
489-32-7
Synonyms
ICARIN
Icariln
ICARRIN
Icraiin
Icariil
Icariin
ICARIINE
Ieariline
ICARIIN(P)
Epimedim P.E
Epimedium P.E
Epimedium Herb
Icariin Min 90%
Icariin(Icariine
epimedium extract
Epimedium herb Ext
Epimedium/Icariin
ICARIIN, 98+% BY HPLC
ICARIDININSECTREPELLENT
Horny goat weed extract
Epimedim Brevicormum P.E
Shorthorned Epimedium P.E
Epimedium Brevicornum P.E
EpiMediuM breviconuM P.E.
EpiMediuM BreviconuM P.E.(Icariin)
ICARIIN, EPIMEDIUM PLANT EXTRACT 90%
ICARIIN, 99+% HPLC (PRIMARY STANDARD)
Icariin, froM EpiMediuM davidii Franch
EpiMediuM Leaf Extract, Icariin 10% by HPLC
2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-
4H-1-Benzopyran-4-one,3-[(6-deoxy-α-L-mannopy
ranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-
4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside
3-(6-Deoxy-α-L-mannopyranosyloxy)-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Icariin Min 90% SynonyMs 3-[(6-Deoxy-alpha-L-Mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-Methoxyphenyl)-8-(3-Methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
EINECS(EC#)
610-440-0
Molecular Formula
C33H40O15
MDL Number
MFCD00210516
MOL File
489-32-7.mol
Molecular Weight
676.66

Chemical Properties

Melting point 
223-225 ºC
mp 
223-225 ºC
Boiling point 
948.5±65.0 °C(Predicted)
alpha 
D15 -87.09° (in pyridine)
density 
1.55
RTECS 
DJ2980500
storage temp. 
room temp
solubility 
DMSO: soluble50mg/mL, clear, colorless to dark yellow
pka
5.90±0.40(Predicted)
form 
Powder
color 
light yellow to yellow
λmax
350nm(MeOH)(lit.)
Merck 
14,3617
InChIKey
TZJALUIVHRYQQB-XLRXWWTNSA-N

Questions And Answer

Applications

Icariin inhibits the ROS-dependent JNK and p38 pathways.


Description
Icariin is one of the major flavonoids of the herb Epimedium, which has long been used in Tranditional Chinese Medicine to treat bone fracture and prevent osteoporosis. Research has shown that icariin should be an effective component for the bone-strengthening activity of the herb Epimedium, and one of the possible mechanisms for this activity is to stimulate the proliferation and enhance the osteogenic differentiation of marrow stromal cells. Icariin is reported to prevent and treat sexual dysfunction related diseases and improve the use of vasoconstriction. Icariin is used to prepare angiotensin converting enzyme inhibitor medicines, which can be used to treat hypertension-complicated coronary diseases.
References
[1] K. M. Chen, B. F. Ge, H. P. Ma, X. Y. Liu, M. H. Bai, Y, Wang (2005) Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells, 60, 939-942
[2] Patent CN 1199647C “Application of icariin in preparation of medicine for preventing and treating sexual dysfunction”
[3] Patent CN 104739851 A “New application of icariin, or icariin derivatives or icariin salt”

Hazard Information

Chemical Properties
Light yellow to yellow solid
Usage
hepatoprotective
Uses
hepatoprotective
General Description
Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.

Biochem/physiol Actions
Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.

Safety Data

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29389000
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