485-19-8

Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca²⁺ channel blockade and/or 3) inhibition of Ca²⁺ release from norepinephrine-sensitive intracellular stores^[2].