481-53-8

Yellow powder

Tangeretin[481-53-8] has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae. It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells.

ChEBI: Tangeretin is a pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8. It has a role as an antineoplastic agent and a plant metabolite.

Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata.

Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines.

[1] K. AGRAWAL Y. M. Tangeretin: A Biologically Potential Citrus Flavone[J]. Current Traditional Medicine, 2022. DOI:10.2174/2215083808666220304100702.
[2] JUHEE SEO . Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation[J]. European journal of pharmacology, 2011, 673 1: Pages 56-64. DOI:10.1016/j.ejphar.2011.10.011.
[3] Z CHENG. Tangeretin and its metabolite 4′-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K[J]. British Journal of Pharmacology, 2010, 162 8: 1781-1791. DOI:10.1111/j.1476-5381.2010.01185.x.
[4] GUY LEWIN*. Semisynthesis of Natural Flavones Inhibiting Tubulin Polymerization, from Hesperidin[J]. Journal of Natural Products , 2010, 73 4: 702-706. DOI:10.1021/np100065v.
[5] WASEEM RAZA Abha M Suaib Luqman. Prospects of tangeretin as a modulator of cancer targets/pathways[J]. Pharmacological research, 2020, 161: Article 105202. DOI:10.1016/j.phrs.2020.105202.