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• Organic zinc supplementation agent

  Zinc can activate a variety of important antioxidant enzymes, thereby eliminating the damage of oxygen free radicals, maintaining the normal permeability of the cell membrane to protect the normal biochemical composition of cell membranes, metabolic structure and function. Zinc can not only induce the activation of T lymphocyte but also activate the B lymphocytes. Zinc is also involved in antibody formation and release, and stimulating immune cells to secrete a variety of cytokines. Lack of zinc in elderly people can cause immune function disorder; zinc can affect the synthesis of insulin, secretion, storage, degradation and biological activity, being the major trace amount element directly affecting the insulin physiology. Zinc can improve the body's sensitivity to insulin.
  Zinc gluconate is an organic zinc supplement with fewer side effects than zinc sulfate and better absorption as well. It has certain efficacy on the treatment of zinc deficiency caused growth retardation, malnutrition, anorexia, recurrent oral ulcers, acne and senile zinc deficiency as well as immune dysfunction. It is mainly absorbed in the small intestine after oral administration with 1h reaching the peak but declining at about 2h. In the body, it is widely distributed in the liver, intestine, spleen, pancreas, heart, kidney, lung, muscle, central nervous system and bone. It is mainly excreted by the feces with a small amount excreted through the urine and milk. The bioavailability of it is about 1.6 times as high as that of zinc sulfate.
  This product can be used to delay aging, enhance immune response, treatment of non-insulin-dependent diabetes. Oral administration amount calculated on zinc element is 10~25 mg 2 times per day and administrated after meals. Adverse reactions after meal mainly include stomach discomfort, nausea, vomiting. Zinc gluconate should not be subject to fasting medication and should not be overdosed which can affect the absorption of iron.;

• Uses

  Zinc gluconate is an excellent nutrient zinc enhancer, having significant effect for the intellectual and physiological development of infants and young people with its absorption effect being better than inorganic zinc. China provides that it can be used for salt with the usage amount of 800~1000mg/kg; 230~470mg/kg in dairy product; 195~545mg/kg in infant and child food; in cereals and their products: 160~320mg/kg; 40 to 80 mg/kg in beverages and milk beverages.;

• Production method

  There are many routes of synthesis of gluconate zinc with reasonable ways including fermentation, air catalytic oxidation and calcium gluconate indirect synthesis.
  Fermentation
  Take glucose as raw materials with Aspergillus fermentation (oxidation) to generate into gluconic acid. After separation, purification, gluconate is neutralized by zinc oxide or zinc hydroxide for preparation of zinc gluconate.
  C6H12O6 + O2 [Aspergillus niger] → C6H11O6OH [ZnO] → (C6H11O6O) 2Zn + H2O
  The method is mainly used domestically and abroad, the reaction is simple; easy to get raw materials; low cost, but the fermentation process requires a higher technology.
  Air catalytic oxidation method
  Under the presence of the catalyst, the glucose is oxidized by air to produce gluconic acid; and then the sodium hydroxide solution is added dropwise to until the pH value reaches 9.0 to 10.0 so as to be converted into sodium gluconate; after filtering and separating the catalyst, the sodium gluconate solution is oxidized by strong acid cations exchange resin into high-purity gluconic acid solution; finally reacted with zinc oxide or zinc hydroxide to form zinc gluconate with concentration, crystallization and re-crystallization to obtain the product with the yield being over 80%.
  C6H12O6 + O2 [catalyst] → C6H11O6OH [NaOH] → C6H11O6ONa + H2O
  C6H11O6Ona [R-H] → C6H11O6OH [ZnO] → (C6H11O6O) 2Zn + H2O
  The method is easy to obtain raw materials with low cost and good product quality.
  Indirect synthesis from calcium gluconate
  Calcium gluconate, after being acidified by sulfuric acid is filtered to remove calcium sulfate precipitate to generate gluconic acid solution, which after being purified by ion exchange resin, has reaction with zinc oxide or zinc hydroxide to generate zinc gluconate; further carry out filtration, crystallization and drying to get the finished product.
  (C6H11O6O) 2Ca [H2SO4] → C6H11O6OH [ZnO] → (C6H11O6O) 2Zn + H2O
  Add 27 mL (0.5 mol) concentrated sulfuric acid to 500 mL water; successively add 224 g (0.5 mo1) of calcium gluconate and the reaction was carried out at 90 ° C for 1.5 h. The calcium sulfate precipitate was filtered off to give a pale yellow liquid. After cooling, the liquid flowed at a flow rate corresponding to resin volume per minute through the exchange column equipped with the same amount of anion and cation exchange resin to obtain a colorless transparent gluconic acid solution with the relative density of 1.10 to 1.12. The content is 20% and the yield is 95%.
  Take 0.1 mol of gluconic acid solution, and separately add 4.1 g (0.05 mol) of zinc oxide for reaction at 60 ° C for 2 hours. Add drop wise of gluconate liquid to pH=5.7 at the same time and concentrate the 1/3 the volume of the original volume. Add 10 mL 95% ethanol and stand 8 h. The product was purified by crystallization, separation and vacuum drying to obtain 21.8 g product with a 96% yield and purity of 99.3%.
  It can be obtained through the neutralization between zinc oxide and gluconic acid.;

• Identification test

  The zinc test (IT-33) of the 10% sample liquid was positive.
  Take 5 mL of 10% warm sample solution; add 0.7 ml acetic acid and 1 ml new distillated phenylhydrazine for heating in the steam bath for 30min, let it cool. Scratch the inner wall of container with glass rod and it should produce gluconic acid phenylhydrazine crystals.;

• Content analysis

  Weigh approximately 700 mg of the sample, dissolve it in 100 ml of water (heat if necessary); add 5 ml of ammonia-ammonium chloride buffer solution (TS-12) and 0.1 ml of wool chromium black test solution (TS-97). Apply 0.05mol/L of EDTA disodium titration solution for titration to blue color. Each mL of 0.05 mL/L of EDTA disodium corresponds to 22.78 mg of zinc gluconate (C12H22O14Zn).;

• Usage limit

  GB 14880-94 (mg/kg): dairy products 230~470; infant food 195~545; cereals and their products, beverages 80~160; salt: 500.
  FDA, §182.5988 (2000): take GMP as limit.
  GB 2760-2000: soft drinks 21.0~56mg/kg; children over one year old and children milk powder, 0.05~1.175g/kg (all in Zn).
  According to the provisions of Japan, it is allowed to be used in breast milk substitute. The zinc content in per liter of standard milk concentration of breast milk substitute shall not exceed 6mg.;

• Chemical properties

  It appears as white particles or crystalline powder with its molecule either containing or not containing three molecules of crystal water, being odorless and tasteless. It is easily soluble in water and slightly soluble in ethanol. Female mice by oral have a LD50 of 1.93g/k; male mice through oral have a LD50 of 2.99g/kg.;

• Toxicity

  GRAS (FDA, § 182.8988, 2000); LD50 3.06 g/kg (mouse, oral);;

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