4430-42-6

Berteroin is a sulforaphane analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil. At 1.7 μM, it has been shown to double the phase II enzyme quinone reductase activity in mouse hepatoma cells. Berteroin exerts anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages, inhibiting degradation of IκBα, as well as NF-κB p65 translocation to the nucleus and DNA binding activity. It also suppresses IRAK degradation and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt.

Pale yellow liquid; penetrating radish-like aroma

Reported found in radish and horseradish.

Berteroin is a compound with high odor potency occurring in horseradish ( Armoracia rusticana)

ChEBI: Berteroin is an isothiocyanate.

High strength odor; recommend smelling in a 0.01% solution or less.

This sulforaphane analogue and antimetastatic agent (FW = 175.43 g/mol; CAS 4430-42-6; Physical State = Liquid; Soluble in ethanol, DMSO, and chloroform; Store at -20° C; M.P. = 155-156° C), also named 5- methylthiopentyl isothiocyanate, is found in cruciferous vegetables (including Chinese cabbage and rucola leaves) and mustard oil. Berteroin inhibits LPS-induced degradation of Inhibitor of κBα (or IκBα) as well as NF-κB p65 translocation into the nucleus and DNA binding. Berteroin also suppresses degradation of IL-1 Receptor Associated Kinase and phosphorylation of Transforming Growth Factor β-Activated Kinase-1. Berteroin also inhibits LPS-induced phosphorylation of p38 MAPK, ERK1/2, and AKT

[1] YOO JIN JUNG. Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin.[J]. International Journal of Molecular Sciences, 2014, 15 11: 20686-20705. DOI: 10.3390/ijms151120686
[2] Y ZHANG. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89 6: 2399-2403. DOI: 10.1073/pnas.89.6.2399