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439-14-5

Name Diazapam
CAS 439-14-5
EINECS(EC#) 207-122-5
Molecular Formula C16H13ClN2O
MDL Number MFCD00057323
Molecular Weight 284.74
MOL File 439-14-5.mol

Chemical Properties

Appearance Diazepam is a yellow crystalline powder.
Melting point  131.5-134.5°C
Boiling point  497.4±45.0 °C(Predicted)
density  1.2245 (rough estimate)
refractive index  1.6330 (estimate)
Fp  11 °C
storage temp.  2-8°C
solubility  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL
form  A neat solid
pka 3.4(at 25℃)
Stability: Stable. Light-sensitive. Incompatible with strong oxidizing agents.
Water Solubility  50mg/L(25 ºC)
Usage Anxiolitic; muscle relaxant (skeletal); anticonvulsant. Controlled substance (depressant)
BCS Class 1
CAS DataBase Reference 439-14-5(CAS DataBase Reference)
IARC 3 (Vol. Sup 7, 66) 1996
NIST Chemistry Reference 2H-1,4-benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-(439-14-5)
EPA Substance Registry System 439-14-5(EPA Substance)

Safety Data

Hazard Codes  Xn,T,F,Xi
Risk Statements 
R21/22:Harmful in contact with skin and if swallowed .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
RIDADR  UN 2811 6.1/PG 3
WGK Germany  2
RTECS  DF1575000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933910000
Safety Profile
Poison by ingestion, parenteral, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. Questionable carcinogen with experimental tumorigenic data. Human systemic effects: dermatitis, effect on inflammation or mediation of inflammation, change in cardiac rate, somnolence, respiratory depression, and other respiratory changes, visual field changes, diplopia (double vision), change in motor activity, muscle contraction or spasticity, ataxia (loss of muscle coordination), an antipsychotic and general anesthetic. Human reproductive effects by ingestion and intravenous routes causing developmental abnormalities of the fetal cardiovascular (circulatory) system and postnatal effects. Experimental teratogenic and reproductive effects. Human mutation data reported. An allergen. A drug for the treatment of anxiety. When heated to decomposition it emits very toxic fumes of Cl and NOx.
Hazardous Substances Data 439-14-5(Hazardous Substances Data)
Toxicity
LD50 oral in rabbit: 328mg/kg

Hazard Information

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