Synthesis
1. The compound (CAS: 77287-34-4) was mixed with diethyl 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylate in formamide (8 mL) and 20 wt% acetic acid (2 g) was added.
2. The reaction mixture was heated at 120°C for 24 hours.
3. Upon completion of the reaction, it was cooled to room temperature and water (32 mL) was slowly added to precipitate the target product, ethyl 5-methyl-4-oxo-3,4-dihydropyrrolo[1,2-F][1,2,4]triazine-6-carboxylate.
4. The precipitated solid was collected by filtration and washed with ethyl acetate (EtOAc).
5. Drying gave the target compound as a yellow solid in 90% yield.
References
[1] Patent: US2006/235020, 2006, A1. Location in patent: Page/Page column 20
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 1, p. 4 - 16
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 21, p. 4774 - 4779
[4] Patent: US2006/3967, 2006, A1. Location in patent: Page/Page column 8
[5] Patent: US2006/229449, 2006, A1. Location in patent: Page/Page column 6
![Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester](/CAS/GIF/427878-70-4.gif)