41078-02-8

3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (K_is = 44, 32, and 6.3 μM for A₁, A_2A, and A_2B, respectively) and cAMP phosphodiesterase (K_i = 42 μM). Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.

Bronchodilator.

ChEBI: Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic n uropathy.

A2B receptor: 7 μM (Ki)

Store at -20°C

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