General procedure for the synthesis of 6-bromo-2-methylimidazo[1,2-a]pyridine from 2-amino-5-bromopyridine and chloroacetone: 2-amino-5-bromopyridine (6.2 g) was dissolved in ethanol (60 mL), followed by chloroacetone (5.7 mL). The reaction mixture was heated to 90 °C and refluxed for 16 hours under stirring conditions. Upon completion of the reaction, the mixture was cooled and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (Biotage, 100 g) using a gradient elution of dichloromethane with methanol (2-15%) to yield 6-bromo-2-methylimidazo[1,2-a]pyridine (6.1 g, 80.6% yield) as a yellow solid.1H NMR (500 MHz, CD3OD) δ 9.03 (s, 1H),. 8.02 (m, 1H), 7.93 (s, 1H), 7.79 (d, J=9.4Hz, 1H), 2.56 (d, J=1.0Hz, 3H).
![6-BROMO-2-METHYLIMIDAZO[1,2-A]PYRIDINE](/CAS/GIF/4044-99-9.gif)