4-deoxy-4α-Phorbol is a tetracyclic diterpene found in croton oil.1,2 It has been used in the semisynthesis of inhibitors of the HIV-1-induced cytopathic effect on MT-4 cells and 4α-phorbol esters.
References
1. El-Mekkawy, S., Meselhy, M.R., Abdel-Hafez, A.A., et al. Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives Chem. Pharm. Bull. (Tokyo) 50(4),523-529(2002). 2. Klausen, T.K., Pagani, A., Minassi, A., et al. Modulation of the transient receptor potential vanilloid channel TRPV4 by 4α-phorbol esters: A structure-activity study J. Med. Chem. 52(9),2933-2939(2009).
