371215-02-0

BZX1 is a novel inhibitor of O-GlcNAc transferase (OGT) activity.

OGT-IN-1 (Compound 5) is a potent OGT inhibitor. OGT-IN-1 inhibits sOGT and ncOGT with IC50s of 27 and 10 μM, respectively[1].

[1] Gross BJ, et al. Discovery of O-GlcNAc transferase inhibitors. J Am Chem Soc. 2005 Oct 26;127(42):14588-9. DOI:10.1021/ja0555217