368874-13-9

Anti-Claudin-1 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry

Claudin-1 directly interacts with tight junction (TJ) -associated peripheral membrane proteins zonula occludens (ZO) proteins -1/2/3. Defects in the gene encoding claudin-1 are the cause of an autosomal recessive syndrome named ichthyosis-sclerosing cholangitis neonatal (NISCH). Claudinsμ expression is altered in several human cancers. Claudin-1 is frequently up-regulated in colorectal carcinomas (CRCs)resulting in tumor differentiation and progression.