365462-61-9

AS1468240 is a factor Xa inhibitor with significant oral anticoagulant activity.

AS1468240 is an orally active inhibitor for anticoagulant factor Xa (fXa), that inhibits human fXa with IC50 of 8.7 nM. AS1468240 prolongs the coagulation time in mice[1].

[1] Ishihara T, et al., Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system. Bioorg Med Chem. 2015 Jan 15;23(2):277-89. DOI:10.1016/j.bmc.2014.11.042