Uses
Nandrolone Decanoate is an anabolic steroid. Nandrolone decanoate is used in the treatment of osteoporosis in postmenopausal women. Nandrolone Decanoate is also used for some aplastic anemias.
Control
led Substance.
Description
Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis. The process for creating esters of [nandrolone] was patented in Spain in 1959 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters. Nandrolone decanoate was granted FDA approval on 5 October 1962.
Chemical Properties
White or almost white, crystalline powder.
Originator
Deca-Durabolin,Organon,US,1962
Definition
ChEBI: Nandrolone decanoate is a steroid ester.
Manufacturing Process
1 gram of 19-nortestosterone is dissolved in 3 ml of dry pyridine, after which
the resulting solution is cooled to -20°C. A solution of 1.0 gram of decanoic
acid chloride in 3 ml of dry benzene is added to the cooled solution. The
mixture is maintained at -15°C for 16 hours and then poured into ice water.
The aqueous liquid is extracted with benzene, the benzene solution is washed
with respectively 1 N sodium hydroxide solution, 2 N hydrochloric acid and
with water until neutral reaction.
Then the solution is dried on sodium sulfate, filtered, and evaporated to
dryness. The residue, 1.63 grams is dissolved in hexane, this solution is
filtered over 30 grams of neutral aluminum oxide, and evaporated to dryness.
On paper chromatographic investigation it turned out that the obtained 19-
nortestosterone 17-decanoate which at room temperature is an oil consists of
a single compound, according to US Patent 2,998,423.
Brand name
Durabolin
(Organon);Abolon;Activin;Anabolin la 100;Anador;Anadur;Analone-50;Androlone d 100;Androlone d 50;Decabolin;Deca-durabolin decanoate;Deca-noralone;Docabolin;Fherbolico;Fortabolin;Hybolin-decanoate;Iebolan;Kabolin;Keratyl;Methybol-depot;Nandrolone decanoate;Nordecon;Stenabolin;Sterobolin;Turinabol-depot.
Therapeutic Function
Anabolic
World Health Organization (WHO)
Nandrolone decanoate, an anabolic steroid, was introduced in
1962. In 1982, low dosage preparations were prohibited in Bangladesh due to
inadmissible promotion of products containing anabolic steroids for malnourished
children. Higher dosage preparations of nandrolone decanoate remain available in
many countries, including Bangladesh, for several highly specific but limited
indications that apply to patients with chronic debilitating and emaciating
diseases, particularly associated with neoplasia and some types of aplastic
anaemia.
General Description
Nandrolone decanoate,17β-hydroxyestr-4-en-3-one 17-decanoate, has been used inthe management of certain anemias, but the availability oferythropoietin has greatly reduced this use.
Safety Profile
Experimental reproductiveeffects. When heated to decomposition it emits acridsmoke and irritating fumes.
Veterinary Drugs and Treatments
The principle use of nandrolone in veterinary medicine has been to
stimulate erythropoiesis in patients with certain anemias (e.g., secondary
to renal failure, aplastic anemias). It has also been suggested
for use as an appetite stimulant.
