ChemicalBook CAS DataBase List 340019-69-4

340019-69-4

Name	Cyclopropanecarboxamide, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-3-oxo-1H-isoindol-4-yl]-
CAS	340019-69-4
Molecular Formula	C24H28N2O6S
Molecular Weight	472.55
MOL File	340019-69-4.mol

Chemical Properties

Boiling point	778.5±60.0 °C(Predicted)
density	1.365±0.06 g/cm3(Predicted)
storage temp.	4°C, away from moisture and light
form	Solid
pka	14.38±0.20(Predicted)
color	White to off-white

Hazard Information

Spectrum Detail

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Sampling time(h)		Concentration(ng/ml)
	CC-11050 only		CC-11050+INH
1	1,331.6±136.97		905.35±594.23
2	1,409.47±140.85		1,309.39±214.08
5	948.85±128.7		1,609.18±167.2
8	820.6±265.98		1,271.73±249.18
24	1.27±1.1		4.96±1.85
T_max(h)	2.0		5.0
C_max(ng/ml)	1,410		1,610
AUC_last(ng × h/ml)	10,200		13,900

Animal Model:	B6D2F1 mice^[2]
Dosage:	5, 25, or 50 mg/kg
Administration:	oral, 5, 25, or 50 mg/kg, single
Result:	Reduced PDE4 expression in mtb-infected mouse lungs.

Animal Model:	B6D2F1 mice^[2]
Dosage:	5, 25, or 50 mg/kg
Administration:	oral gavage, 5, 25, or 50 mg/kg, single
Result:	Improved antibiotic-mediated bacterial killing and reduced lung pathology.

340019-69-4

Chemical Properties

Hazard Information

Uses

in vivo

IC 50

References

Spectrum Detail

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