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Primordazine B is a small molecule compound identified by chemical screening in zebrafish embryos with the activity of selectively destroying Primordial Germ Cells (PGCs). Primordazine B inhibits a process called Poly(A)-tail Independent Non-canonical Translation (PAINT) without inhibition of polyadenylate tail dependent typical translation (PAT). Primordazine B can be used to study translational control of cells in specific physiological or pathological states, such as gene expression regulation during cell dormancy, viral infection, or stress conditions[1].

[1] Youngnam N Jin, et al. Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells[J]. Nature chemical biology, 2018, 14(9): 844-852. DOI:10.1038/s41589-018-0098-0