Safrazine (oral; 3, 10, 30 mg/kg) causes the increases contents of monoamine lasted for at least 24 h[1].
Safrazine strongly inhibits both 5-HT and PEA deaminations, but shows no selectivity toward the substrate used[1].
| Animal Model: | Male ddY mice[1] |
| Dosage: | 3, 10, 30 mg/kg |
| Administration: | Oral |
| Result: | Inhibited significantly both 5-HT and PEA deaminations at only 3 mg/kg by 77% and 71%, respectively.
Completely reduced both deaminations at 10 and 30 mg/kg and not observed specificity toward substrates.
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