| Appearance |
light yellow to beige to brown crystalline powder, |
| Melting point |
40-44 °C(lit.)
|
| Boiling point |
96-98 °C8 mm Hg(lit.)
|
| density |
1.4373 (estimate) |
| Fp |
233 °F
|
| storage temp. |
2-8°C
|
| solubility |
sparingly soluble in water, readily soluble in organic solvents. Distribution ratio between acidic water and benzene is about 40. In alkaline aqueous medium it exists in the enolate form, this being relatively more soluble in water. The equilibrium distribution ratio between benzene and alkaline aqueous medium (about pH 8) is about 1. In alkaline aqueous medium of pH > 9 TTA decomposes to trifluoroacetone and acetylthiophen. |
| form |
Crystalline Powder, Crystals and/or Chunks |
| pka |
5.60±0.23(Predicted) |
| color |
Light yellow or beige to brown |
| Odor |
Odorless |
| Water Solubility |
INSOLUBLE |
| Detection Methods |
GC,HPLC,NMR |
| BRN |
168645 |
| Stability: |
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey |
TXBBUSUXYMIVOS-UHFFFAOYSA-N |
| Uses |
2-Thenoyltrifluoroacetone (TTFA) is an inhibitor of respiration in animals and bacteria. In animals, TTFA binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II), preventing ubiquinone from binding. It inhibits NADH fumarate reductase in bacteria. TTFA also inhibits photosystem II in plants and NADH-ubiquinone oxidoreductase of the virus Vibrio cholerae, decreasing cholera toxin production. This compound is also a chelator of metals, including lanthanum, zirconium, hafnium, and neodymium. Reagent for the determination of actinides and lanthanides.
2-Thenoyltrifluoroacetone is used for the extractive spectrophotometric determination of ruthenium at ph 4.0 (acetate buffer).
Thenoyltrifluoroacetone has also been used as an alternative β-diketone for in-house assay development since NTA was not, until recently, commercially available.
|
| CAS DataBase Reference |
326-91-0(CAS DataBase Reference) |
| NIST Chemistry Reference |
1,3-Butanedione, 4,4,4-trifluoro-1-(2-thienyl)-(326-91-0) |
| EPA Substance Registry System |
326-91-0(EPA Substance) |
