321686-01-5

Name	2-(3,4-dimethoxyphenyl)-4-(4-methylphenyl)-2,3-dihydro-1,5-benzothiazepine
CAS	321686-01-5
Molecular Formula	C24H23NO2S
Molecular Weight	389.51
MOL File	321686-01-5.mol

Synonyms

α-Glucosidase-IN-21 2-(3,4-dimethoxyphenyl)-4-(4-methylphenyl)-2,3-dihydro-1,5-benzothiazepine

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Hazard Information

Uses

α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity[1].

in vivo

α-Glucosidase-IN-21 (Compound 2B; 10 and 20 mg/kg; p.o.; daily, for 4 weeks) has anti-diabetic activity in Streptozocin (HY-13753)-induced diabetic rats^[1].
α-Glucosidase-IN-21 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats^[1].
α-Glucosidase-IN-21 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice^[1].

Animal Model:	Male Wistar albino rats (170-200 g), Streptozotocin-induced diabetes model^[1]
Dosage:	10 and 20 mg/kg
Administration:	Oral administration; daily, for 4 weeks
Result:	Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.

References

[1] Mehmood R, et al. Synthesis of Novel 2, 3-Dihydro-1, 5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies. ACS Omega, 2022 Aug 17.

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Telephone 15002134094

Websitehttps://www.targetmol.cn/

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