ChemicalBook CAS DataBase List 31314-39-3

31314-39-3

Name	Prodipine (hydrochloride)
CAS	31314-39-3
Molecular Formula	C17H19N.ClH
Molecular Weight	315.89
MOL File	31314-39-3.mol

Chemical Properties

Melting point	267°
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
color	Off-white to yellow

Safety Data

HS Code

2933399990

Hazard Information

Uses

Prodipine, a diphenyl-phosphonate derivative. The IC50s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively.

Biological Activity

Prodipine (hydrochloride) is a diphenylphosphonate derivative. Inhibits dipeptidyl peptidase IV (DPP IV) in purified rabbit and plasma with IC50 of 4.5 μM and 30 μM, respectively.

in vitro

Prodipine (hydrochloride), a diphenyl-phosphonate derivative selected from a group of slow-binding irreversible inhibitors of this enzyme. The IC ₅₀ values of Prodipine for purified and plasma DPP IV from the rabbit are 4.5 μM and 30 μM, respectively.

in vivo

Male rabbits weighing 3-4 kg receive a single intravenous injection with 10 mg Prodipine (hydrochloride) or saline. After 1 hr, plasma DPP IV activity has decreased to less than 20% of the preinjection value and remains unchanged during a 24 hr observation period. A profound and long-lasting inhibition of plasma DPP IV activity is observed in the treated animals (1, 5 or 10 mg). It takes 5 to 8 days to reach half of the pretreatment DPP IV activity and generally more than 20 days for a complete recovery.

target

IC50: 4.5 μM (purified DPP IV), 30 μM (plasma DPP IV)

IC 50

DPP-4

storage

Store at -20°C

References

[1] De Meester I, et al. In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-diphenyl-phosphonate (Prodipine). Biochem Pharmacol. 1997 Jul 1;54(1):173-9. DOI:10.1016/s0006-2952(97)00149-4

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