ChemicalBook CAS DataBase List 302-84-1

302-84-1

Name	DL-Serine
CAS	302-84-1
EINECS(EC#)	206-130-6
Molecular Formula	C3H7NO3
MDL Number	MFCD00064223
Molecular Weight	105.09
MOL File	302-84-1.mol

Synonyms

(+/-)-2-AMINO-3-HYDROXYPROPIONIC ACID 2-AMINO-3-HYDROXY-PROPIONIC ACID DL-2-AMINO-3-HYDROXYPROPANOIC ACID DL-2-AMINO-3-HYDROXYPROPIONIC ACID DL-BETA-HYDROXYALANINE DL-SER DL-SERINE H-DL-SER-OH SERINE (R,S)-2-Amino-3-hydroxy-propionicacid L-HOCH2CH(NH2)COOH Serine, dl- DL-SERINE CELL CULTURE TESTED DL-SERINE 99+% Dl-SerinePuriss99+% Dl-SerinePuriss DL-SERINE FOR BIOCHEMISTRY (n)-2-amino-3-hydroxypropionic acid DL-SERINE,FCC DL-Serin

Chemical Properties

Appearance	White crystalline powder
Melting point	240 °C (dec.) (lit.)
Boiling point	197.09°C (rough estimate)
density	1.53
refractive index	1.4368 (estimate)
storage temp.	Store at RT.
solubility	H2O: soluble
form	Crystalline Powder
pka	2.19(at 25℃)
color	White
Odor	Odorless
Water Solubility	50.23 g/L (25 ºC)
Merck	14,8460
BRN	1721402
Cosmetics Ingredients Functions	FRAGRANCE HAIR CONDITIONING ANTISTATIC SKIN CONDITIONING
InChI	1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)
InChIKey	MTCFGRXMJLQNBG-UHFFFAOYSA-N
SMILES	NC(CO)C(O)=O
LogP	-3.460
Uses	serine is a hydrophilic amino acid. Serine helps retain the skin’s moisture balance. less more
CAS DataBase Reference	302-84-1(CAS DataBase Reference)
NIST Chemistry Reference	DL-Serine(302-84-1)
EPA Substance Registry System	302-84-1(EPA Substance)

Safety Data

Hazard Codes	Xi
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S24/25:Avoid contact with skin and eyes . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . less more
WGK Germany	3
RTECS	VT8100000
TSCA	Yes
HS Code	29225000
Storage Class	11 - Combustible Solids
Safety Profile	When heated to decomposition emits toxic fumes of NOx. less more

Raw materials And Preparation Products

Hazard Information

Description

DL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.

Chemical Properties

DL-Serine is a kind of colorless monoclinic columnar or lamellae crystal. It is soluble in water (at 20℃, the water solubility is 380g/L), insoluble in ether and ethanol; Decomposition point: 246℃.

Application

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer?s treatment.

Definition

ChEBI: An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Preparation

DL-serine is obtained by complexing glycine under the catalysis of copper ions and then combining with formaldehyde under alkaline conditions, followed by acidification, ion exchange, and crystallization in ethanol.?

Synthesis Reference(s)

Canadian Journal of Chemistry, 33, p. 1119, 1955 DOI: 10.1139/v55-131
The Journal of Organic Chemistry, 35, p. 1505, 1970 DOI: 10.1021/jo00830a054

Biochem/physiol Actions

NMDA agonist acting at the glycine site; precursor of glycine by serine hydroxymethyltransferase

in vitro

DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).
Subcutaneous injection of DL-serine increases the number and size of renal tubular cell tumors in male W rats treated with 500 or 1,000 ppm N-ethyl-N-hydroxyethylnitrosamine.

Material Safety Data Sheet(MSDS)

Spectrum Detail

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