Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo[1].
in vivo
Antimalarial agent 25 (compound 8) (30 mg/kg; po; once daily for 4 consecutive days) shows antimalarial activity in female albino swiss mice[1].
Antimalarial agent 25 (300 mg/kg; po; single dose) shows no significant pathological changes and histopathological damage in female mice[1].
Animal Model:
Mice infected with Plasmodium berghei ANKA[1]
Dosage:
30 mg/kg
Administration:
Oral administration; for 4 consecutive days
Result:
Partly reduced P. berghei infection.
Parasitemia decreased by 33% on the seventh day (post-treatment).
References
[1] Costa Souza RM, et al. Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control. Eur J Med Chem. 2023 Jul 5;255:115400. DOI:10.1016/j.ejmech.2023.115400
