Uses
Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206μM for MMP-1, 15μM for MMP-3, 96μM for MMP-7, and 4μM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.
Enzyme inhibitor
This thiirane (FW = 306.41 g/mol), also known as matrix
metalloproteinase-2/matrix metalloproteinase-9 inhibitor IV (MMP-
2/MMP-9 inhibitor IV) and SB-3CT, is a mechanism-based inhibitor of
gelatinase A, or matrux metalloproteinase 2, Ki = 0.014 μM, gelatinase
B, or matrix metalloproteinase 9, Ki = 0.6 μM, membrane-type matrix
metalloproteinase 1, matrix metalloproteinase 14, matrilysin, Ki = 96
μM, stromelysin 1, or matrix metalloproteinase 3, Ki = 15 μM.
