2925261-76-1

hCAIX-IN-18 (compound 30) is an inhibitor of carbonic anhydrase (CA), with Kis of 3.5 nM, 9.4 nM, 43.0 nM and 8.2 nM for hCAI, hCAII, hCAIX, hCAXII, respectively. hCAIX-IN-18 can be used for cancer research[1].

hCA I: 3.5 nM (IC₅₀); hCA II: 9.4 nM (IC₅₀); hCA IX: 43 nM (IC₅₀); hCA XII: 8.2 nM (IC₅₀)

[1] 1. Peerzada MN, et al. Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors. ACS Med Chem Lett. 2023 May 8;14(6):810-819. DOI:10.1021/acsmedchemlett.3c00094