2924064-10-6

Name	GPR183-IN-2
CAS	2924064-10-6

Synonyms

GPR183-IN-2

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Chemical Properties

form	Solid
color	White to off-white

Hazard Information

Uses

GPR183-IN-2 (compound 23) is a potent GPR183 inhibitor. GPR183-IN-2 inhibits Ca2+ mobilization with an IC50 value of 39.45 nM. GPR183-IN-2 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis[1].

in vivo

Pharmacokinetic Parameters^[1].

Parameters	CL (mL/min/kg)	T_1/2 (h)	C_max (ng/mL)	AUC_0-t (ng?h/mL)	V_ss (L/kg)	F (%)
IV 1 mg/kg	10.17	1.91	965	1575	1.50	-
PO 10 mg/kg	-	4.58	5108	28042	-	224.50

References

[1] Jian Bei Xi, et al. Compounds and their use as GPR183 inhibitors. CN118201911A.

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Shanghai SuperLan Chemcial Technique Centre

Telephone0-2022843681 15618226720

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19886/0_EN.htm

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Guangzhou New Century Technology Co., Ltd.

Telephone020-13113998854 13113998854

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList32626/0_EN.htm

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