Potential Exposure
Used to make other chemicals, coat ings, and polyurethane. It is also used as a hardener in
automobile and airplane paints.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, includ ing resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medi cal attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Medical observation is recommended for 24 to 48 hours
after breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or
authorized paramedic may consider administering a drug or
other inhalation therapy.
Incompatibilities
May form explosive mixture with air.
Isocyanates are highly flammable and reactive with many
compounds, even with themselves. Incompatible with oxi dizers (chlorates, nitrates, peroxides, permanganates, per chlorates, chlorine, bromine, fluorine, etc.); contact may
cause fires or explosions. Reaction with moist air, water or
alcohols may form amines and insoluble polyureas and
react exothermically, releasing toxic, corrosive or flamma ble gases, including carbon dioxide; and, at the same time,
may generate a violent release of heat increasing the con centration of fumes in the air. Incompatible with amines,
aldehydes, alkali metals, ammonia, carboxylic acids, capro lactum, alkaline materials, glycols, ketones, mercaptans,
hydrides, organotin catalysts, phenols, strong acids, strong
bases, strong reducing agents such as hydrides, urethanes,
ureas. Elevated temperatures or contact with acids, bases,
tertiary amines, and acyl-chlorides may cause explosive
polymerization. Attacks some plastics, rubber and coatings.
Contact with metals may evolve flammable hydrogen gas.
May accumulate static electrical charges, and may cause
ignition of its vapors. Temperatures above 200℃ can cause
polymerization. Attacks copper.
Uses
PolyHDI can be used as a compatibilizer to increase the complex viscosity of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/poly(lactic acid) biopolymer based blends. It can be used as a hardener that can be mixed with polyol resins to form polyurethane coatings with a wide range of applications like self-cleaning.
References
[1]Xu, P., Xin, J., Shi, R., Wang, H., Bi, R., & Li, G. (2026). Synthesis Mechanism and Performance Evaluation of the Viscosity Adjustable Hexamethylene Diisocyanate Trimer. Industrial & Engineering Chemistry Research, 65(13), 6820–6832.
https://doi.org/10.1021/acs.iecr.5c04848
