PD-L1/PD-1-IN-1 (compound 8j) is a potent inhibitor of PD-L1/PD interaction, with IC50 ＜ 1 nM. PD-L1/PD-1-IN-1 plays an important role in anti-tumor research[1].
References
[1] Damian Muszak, et al. Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction. J Med Chem. 2021 Aug 12;64(15):11614-11636. DOI:10.1021/acs.jmedchem.1c00957
