2751323-21-2

Name	JAK-IN-5 hydrochloride
CAS	2751323-21-2
Molecular Formula	C27H32ClFN6O
Molecular Weight	511.04
MOL File	2751323-21-2.mol

Synonyms

JAK-IN-5 hydrochloride JAK IN 5 hydrochloride,JAKIN5 hydrochloride JAK-IN-5 hydrochloride(2096999-92-5 Free base)

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Chemical Properties

form	Solid
color	Off-white to light yellow

Hazard Information

Uses

JAK-IN-5 hydrochloride is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283[1].

in vivo

JAK-IN-5 hydrochloride (compound 1) (oral aspirate, 0.5 mg/mL, 50 μL ) inhibits STAT6 phosphorylation by 60% in IL-13-induced in lung tissue in a mouse model of pSTAT6 induction^[2].
JAK-IN-5 hydrochloride (compound 1) (oral aspirate, 0.1-1.0 mg/mL, 50 μL) inhibits 88% of BALF eosinophils in male C57 mice model of Alternaria alternata-induced eosinophilic inflammation of the lung^[2].

References

[1] Paul R. Fatheree, et al. JAK Kinase Inhibitor Compounds for Treatment of Respiratory Disease. US20170121327A1.
[2] Venkat R, et al. Methods of treatment using a jak inhibitor compound. US20180311226.

Supplier

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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