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Anticancer agent 15 is capable of significantly increasing the cellular level of ROS and inducing melanoma cancer cell death via necroptosis.

[1] Zhang K, et al. A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells. J Med Chem. 2021 Nov 11;64(21):15825-15845. DOI:10.1021/acs.jmedchem.1c01123