268545-87-5

Name	NBI 34041
CAS	268545-87-5
Molecular Formula	C22H26Cl2N4
MDL Number	MFCD18782661
Molecular Weight	417.37
MOL File	268545-87-5.mol

Synonyms

SB723620 SB-723620 NBI 34041 SB 723620 AKLMUGFDGONMAA-UHFFFAOYSA-N 6H-1,3,6,8a-Tetraazaacenaphthylene, 2-(2,4-dichlorophenyl)-7,8-dihydro-4-methyl-6-(1-propylbutyl)-

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Hazard Information

Uses

NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.

in vivo

NBI-34041 (3-30 mg/kg; oral gavage; a single dose) significantly attenuates the elevation in plasma ACTH induced by CRF. NBI-34041 also demonstrates efficacy in attenuating shock-induced ACTH release in a dose-dependent manner^[1].

Animal Model:	Male Wistar or Sprague-Dawley rats (300-350 g)^[1]
Dosage:	3 mg/kg, 10 mg/kg, or 30 mg/kg
Administration:	Oral gavage; a single dose
Result:	Did not impair diurnal adrenocorticotropic hormone (ACTH) and cortisol secretion or CRF evoked ACTH and cortisol responses but attenuated the neuroendocrine response to psychosocial stress.

IC 50

CRFR1: 58.9 nM (IC₅₀); CRFR1: 4 nM (Ki); CRFR2: >10000 nM (IC₅₀)

References

[1] Marcus Ising, et al. High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology. 2007 Sep;32(9):1941-9. DOI:10.1038/sj.npp.1301328

Supplier

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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