2676156-05-9

Name	4-Quinazolinamine, N-(4-chloro-3-ethynylphenyl)-6,7-dimethoxy-
CAS	2676156-05-9
Molecular Formula	C18H14ClN3O2
Molecular Weight	339.78
MOL File	2676156-05-9.mol

Synonyms

UNC-CA359 4-Quinazolinamine, N-(4-chloro-3-ethynylphenyl)-6,7-dimethoxy-

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Chemical Properties

Boiling point	488.3±45.0 °C(Predicted)
density	1.36±0.1 g/cm3(Predicted)
pka	5.52±0.30(Predicted)

Hazard Information

Uses

UNC-CA359 is a potent epidermal growth factor receptor (EGFR) inhibitor, with an IC50 value of 18 nM. UNC-CA359 exhibits strong anti-tumor activity, can be used to Chordoma research[1]. UNC-CA359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] Bieberich AA, et al. Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform. Sci Rep. 2022 Jul 27. 12(1):12820. DOI:10.1038/s41598-022-15552-5
[2] Asquith CRM, et al. Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships. ChemMedChem. 2020 Jan 7. 15(1):26-49. DOI:10.1002/cmdc.201900521

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone021-13816613772 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0.htm

Tianjin Kailiqi Biotechnology Co., Ltd.

Telephone 15076683720

Websitehttp://www.cw-bio.com

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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