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Clamikalant sodium (HMR 1098) is an ATP-sensitive potassium (KATP) channel blocker. Clamikalant sodium can be used for the research of arrhythmia[1].

HMR-1098 is a potent and selective blocker of the sarcolemmal ATP-sensitive K+ (sarcKATP) channel. HMR 1098 is inhibits Kir6.2/SUR1-composed KATP channels.

[1] Garrett J Gross, et al. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol. 2013 Jun;59:20-9. DOI:10.1016/j.yjmcc.2013.02.003
[2] Hai-yan Zhou, et al. Improved myocardial function with supplement of levosimendan to Celsior solution. J Cardiovasc Pharmacol. 2014 Sep;64(3):256-65. DOI:10.1097/FJC.0000000000000115
[3] Xiaohui Zhang, et al. Sarcolemmal ATP-sensitive potassium channel protects cardiac myocytes against lipopolysaccharide-induced apoptosis. Int J Mol Med. 2016 Sep;38(3):758-66. DOI:10.3892/ijmm.2016.2664