ChemicalBook CAS DataBase List 26159-34-2

26159-34-2

Name	Naproxen sodium
CAS	26159-34-2
EINECS(EC#)	247-486-2
Molecular Formula	C14H14NaO3
MDL Number	MFCD00058507
Molecular Weight	253.25
MOL File	26159-34-2.mol

Synonyms

6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID SODIUM NAPROXEN SODIUM (-)-NAPROXEN SODIUM SALT NAPROXEN SODIUM SALT (S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID SODIUM SALT (S)-6-METHOXY-A-METHYL-2-NAPHTHALENEACETIC ACID, SODIUM SALT (S)-NAPROXEN, SODIUM SALT (-)-SODIUM (S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETATE 6-methoxy-alpha-methyl-,sodiumsalt,(s)-2-naphthaleneaceticaci 6-methoxy-alpha-methyl-,sodiumsalt,l-(-)-2-naphthaleneaceticaci aleve Anaprox apranax l-(-)-6-methoxy-alpha-methyl-2-naphthaleneaceticacidsodiumsalt naprosynsodium sodiumnaprosyn sodiumnaproxen sodium (-)-2-(6-methoxy-2-naphthyl)propionate Naproxen sodium USP.CP NAPROXEN, USP

Chemical Properties

Appearance	White Powder
Melting point	250-251°C
alpha	D -11° (in methanol)
storage temp.	Inert atmosphere,Room Temperature
solubility	Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent).
form	neat
color	White to Off-White
biological source	synthetic (organic)
Water Solubility	Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
Usage	An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory
Major Application	pharmaceutical (small molecule)
InChI	InChI=1/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/s3
InChIKey	CDBRNDSHEYLDJV-OVMXBOEKNA-M
SMILES	C12C=CC(OC)=CC1=CC=C([C@H](C)C([O-])=O)C=2.[Na+] \|&1:11,r\|
CAS DataBase Reference	26159-34-2(CAS DataBase Reference)

Safety Data

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H360
Precautionary statements	P201-P202-P264-P270-P301+P312-P308+P313
Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. less more
Safety Statements	53-45 less more
RIDADR	3249
WGK Germany	3
RTECS	QJ1047000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2918992090
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Oral Repr. 1A

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White Powder

Definition

ChEBI: The sodium salt of naproxen.

Brand name

Aleve (Bayer); Anaprox (Roche);Naprelan (Stat Trade).

General Description

Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

Non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.

Biochem/physiol Actions

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

References

[1]. mendias cl, tatsumi r and allen re. role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. muscle nerve, 2004, 30(4):497-500.
[2]. hinz b, cheremina o, besz d, et al. impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers. int j clin pharmacol ther, 2008, 46(4):180-6.
[3]. sances g, martignoni e, fioroni l, et al. naproxen sodium in menstrual migraine prophylaxis: a double-blind placebo controlled study. headache, 1990, 30(11):705-9.
[4]. tavolari s, bonafè m, marini m, et al. licofelone, a dual cox/5-lox inhibitor, induces apoptosis in hca-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. carcinogenesis, 2008, 29(2):371-80.

Questions And Answer

Non-steroidal anti-inflammatory analgesic
Naproxen sodium is a non-steroidal anti-inflammatory analgesic drug which is more tolerable to human, belonging to the phenylpropionic acid compounds. It plays anti-inflammatory effect by inhibiting prostaglandin synthesis.It is absorbed rapidly after oral administration and the plasma reached the peak concentration within 2 to 4 hours. Food has little effect on the rate of absorption. Naproxen and plasma protein are highly binded(99%); the plasma concentration is between 23~40mcg/ml. The metabolic process is demethylation and then combining with glucuronide; the elimination half-life is 12 to 15 hours, mainly excreted by the urine. Clinical application is to relieve a variety of mild to moderate degree of pain, such as tooth extraction and other postoperative pain, primary dysmenorrhea and headache. It is also used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendinitis, bursitis and acute gouty arthritis; it also plays a role in arthritis pain, swelling and activity restricted symptom. Psoriatic arthritis and Reiter's syndrome can also be treated with this product. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the symptom relief effect was similar, but the incidence and severity of adverse reactions in the gastrointestinal and neurological systems were low. In addition, this product is also the same as aspirin which can inhibit platelet aggregation and prolong bleeding time; but the effect is reversible, and can be restored after stopping.
Naproxen sodium and plasma protein binding rate is high (99%), and other protein-binding drugs can be replaced by its joint out. Therefore, the acceptance of these drugs (such as oral anticoagulants, sulfonylurea, hydantoins) people should observe the interaction effects. At the same time the application of probenecid, naproxen can increase the plasma concentration, half-life period. Magnesium hydroxide, aluminum can make this product absorption rate slightly lower; sodium bicarbonate can make it higher.;
Uses
Used as anti-inflammatory analgesic;

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26159-34-2

Chemical Properties

Safety Data

Raw materials And Preparation Products

Raw materials

Hazard Information

Chemical Properties

Definition

Brand name

General Description

Biological Activity

Biochem/physiol Actions

References

Questions And Answer

Non-steroidal anti-inflammatory analgesic

Uses

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Related Products