HldA/E-IN-1 (compound 8) is a dual inhibitor of HldA/E, with IC50 values ??of 17.2 μM and 67.8 μM for HldA/E, respectively. HldA/E-IN-1 can be used in the study of anti-bacterial infection[1].
IC 50
HldA: 17.2 μM (IC50); HldE: 67.8 μM (IC50)
References
[1] Cao J, et al. Exploring fluorinated heptose phosphate analogues as inhibitors of HldA and HldE, key enzymes in the biosynthesis of lipopolysaccharide. Bioorg Chem. 2024 Aug 30;153:107767. DOI:10.1016/j.bioorg.2024.107767