DA-023 (Compound 4) is a selective positive allosteric modulator (PAM) of EAAT2 with an EC50 value of 1 nM[1].
References
[1] Fontana ACK, et al. Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators. J Med Chem. 2024;67(8):6119-6143. DOI:10.1021/acs.jmedchem.3c01909