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MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers[1].

MMP-9: 5.56 nM (IC₅₀); MMP-1: 447 nM (IC₅₀); MMP-2: 221 nM (IC₅₀); MMP13: 295 nM (IC₅₀); AKT: 2.11 nM (IC₅₀)

[1] Mohammed Salah Ayoup, et al. Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. Eur J Med Chem. 2020 Jan 15;186:111875. DOI:10.1016/j.ejmech.2019.111875