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Glutor is a selective GLUT 1/2/3 inhibitor that can suppress glucose uptake. Glutor can inhibit glycolysis and has anti-tumor activity, inducing cell apoptosis[1][2].

Glutor is a potent inhibitor of glucose uptake th at targets glucose transporters GLUT1-2and -3. Inhibition of glucose uptake by glutor leads to upregulation of GLUT3 and GLUT1 expression. Glutor potently and selectively suppresses growth of a variety of cancer cell lines. Glutor and glutaminase inhibitor CB-839 synergistically inhibit tumor cell growth.

[1] Reckzeh ES, et al. Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth. Cell Chem Biol. 2019;26(9):1214-1228.e25. DOI:10.1016/j.chembiol.2019.06.005
[2] Mithlesh Kumar Temre， et al. Glutor, a Glucose Transporter Inhibitor, Exerts Antineoplastic Action on Tumor Cells of Thymic Origin: Implication of Modulated Metabolism, Survival, Oxidative Stress, Mitochondrial Membrane Potential, pH Homeostasis, and Chemosensitivity. Front Oncol. 2022 Jun 30:12:925666. DOI:10.3389/fonc.2022.925666