2529451-43-0

COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity[1].

COX-2: 17.9 nM (IC₅₀); COX-1: 19.3 μM (IC₅₀)

[1] Li SM, et al. New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study. Bioorg Chem. 2020 Nov;104:104333. DOI:10.1016/j.bioorg.2020.104333